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The Potential of Spatially Detecting SPIONs Using Multiple Sensor Coils

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P. Wolff, L. C. P. Wille, S. Lyer, and J. Kirchner, “The Potential of Spatially Detecting SPIONs Using Multiple Sensor Coils,” IEEE Transactions on Molecular, Biological, and Multi-Scale Communications, vol. 12, pp. 833–838, 2026, doi: 10.1109/tmbmc.2026.3720580

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Detecting magnetic nanoparticles using inductive sensor coils is a proven, feasible, and cost-effective method. Recently, molecular communication in fluids—primarily in models of the vascular system—has been studied. The single-sensor approach is useful for determining the presence of superparamagnetic iron oxide nanoparticles (SPIONs) in the vicinity of the sensor. However, distinguishing between a small number of particles close to the sensor and a larger number farther away remains challenging. To address this, spatial detection using multiple sensors is being investigated. This opens up the possibility of utilizing spatial information in a communication context, as well as enabling imaging options that display the particle distribution across the cross-sectional area of the channel. As a result, the concentration can be determined with greater precision. The stability of the sensors is investigated, demonstrating the reliability of the reference scales for the shift-to-concentration relationship. Nonetheless, the presented approach is subject to several limitations and factors that must be considered in future work. To conclude the presented work, it can be said that advances were made in the position and concentration determination of SPIONs, as well as in a structured investigation of sensor stability.

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DOI 10.1109/tmbmc.2026.3720580

OpenAlex ID W7172507287

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